2. l-Lysine in Rat Liver Mitochondria" style="margin:15px;">
    Author's Information
    P W Scislowski
    The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB2 9SB, U.K.

    A R Foster
    The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB2 9SB, U.K.

    M F Fuller
    The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB2 9SB, U.K.
  3. l-Lysine in Rat Liver Mitochondria" style="margin:15px;">
    Abstract
    The generation of 14CO2 from [1-14C]lysine by hepatic mitochondria through the saccharopine pathway is controlled by intramitochondrial concentrations of lysine, 2-oxoglutarate and NADPH. Mitochondria, isolated from rats pre-treated with glucagon, exhibited higher activities of L-lysine: 2-oxoglutarate reductase, saccharopine dehydrogenase and 2-aminoadipate aminotransferase. The flux through this pathway is stimulated in liver mitochondria after glucagon treatment. Multiple regulation of lysine oxidation in liver mitochondria confirms a complex mechanism of �mitochondrial activation� by glucagon.
    Keywords
    oxidative degradation, rat liver mitochondria, glucagon
    DOI: 10.1042/bj3000887
    ADLID: 79185-v4
  4. l-Lysine in Rat Liver Mitochondria" style="margin:15px;">
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  1. Keywords
    oxidative degradation rat liver mitochondria glucagon
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