2. Author's Information
    Dennis Eickelbeck
    Department of General Zoology and Neurobiology, Ruhr University Bochum, ND7/31, Universitätsstasse 150, 44780 Bochum, Germany

    Till Rudack
    Biospectroscopy, Center for Protein Diagnostics (ProDi), Ruhr University Bochum, Gesundheitscampus 4, 44801 Bochum, Germany

    Stefan Alexander Tennigkeit
    Biospectroscopy, Center for Protein Diagnostics (ProDi), Ruhr University Bochum, Gesundheitscampus 4, 44801 Bochum, Germany

    Tatjana Surdin
    Department of General Zoology and Neurobiology, Ruhr University Bochum, ND7/31, Universitätsstasse 150, 44780 Bochum, Germany

    Raziye Karapinar
    Department of General Zoology and Neurobiology, Ruhr University Bochum, ND7/31, Universitätsstasse 150, 44780 Bochum, Germany

    Jan‐Claudius Schwitalla
    Department of General Zoology and Neurobiology, Ruhr University Bochum, ND7/31, Universitätsstasse 150, 44780 Bochum, Germany

    Brix Mücher
    Department of General Zoology and Neurobiology, Ruhr University Bochum, ND7/31, Universitätsstasse 150, 44780 Bochum, Germany

    Maiia Shulman
    Biospectroscopy, Center for Protein Diagnostics (ProDi), Ruhr University Bochum, Gesundheitscampus 4, 44801 Bochum, Germany

    Marvin Scherlo
    Biospectroscopy, Center for Protein Diagnostics (ProDi), Ruhr University Bochum, Gesundheitscampus 4, 44801 Bochum, Germany

    Philipp Althoff
    Department of Biophysics, Ruhr University Bochum, ND04/596, Universitätsstrasse 150, 44780 Bochum, Germany

    Melanie D. Mark
    Department of General Zoology and Neurobiology, Ruhr University Bochum, ND7/31, Universitätsstasse 150, 44780 Bochum, Germany

    Klaus Gerwert
    Biospectroscopy, Center for Protein Diagnostics (ProDi), Ruhr University Bochum, Gesundheitscampus 4, 44801 Bochum, Germany

    Stefan Herlitze
    Department of General Zoology and Neurobiology, Ruhr University Bochum, ND7/31, Universitätsstasse 150, 44780 Bochum, Germany
  3. Abstract
    Optogenetic control of G protein‐coupled receptor pathways: The Japanese lamprey (Lethenteron camtschaticum) parapinopsin (“UVLamP”) serves as a minimally invasive, narrow‐bandwidth, bistable, next‐generation optogenetic probe for controlling the Gi/o pathway. A millisecond UV light pulse allows for sustained pathway activation that can be switched off with a millisecond blue light pulse on demand. The first structural model of parapinopsin in the dark state reveals novel interaction partners shedding light on the mechanisms responsible for opsin bistability.
    Keywords
    Computational chemistry, electrophysiology, integrative modeling, mutagenesis, optogenetics, structural biology
    DOI: 10.1002/cbic.201900720
    ADLID: 118052-v0
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  1. Keywords
    Computational chemistry electrophysiology integrative modeling mutagenesis optogenetics structural biology
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