2. Author's Information
    Carlos A. M. Afonso
    CQFM, Departmento de Engenharia Química, Instituto Superior Tecnico, 1049-001 Lisboa, Portugal

    Jorge Pereira
    Escola Superior de Tecnologia de Setubal, Campus do Instituto Politecnico de Setubal, Estefanilha, 2910-761 Setubal, Portugal
  3. Abstract
    An asymmetric aldol reaction based on the use of (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one as a chiral auxiliary is described involving a three-step procedure: preparation of the chiral auxiliary from readily available (�)-ephedrine and urea in a solventless fashion, coupling of the chiral auxiliary to the ester functional group, and aldol condensation via in situ formation of the corresponding boron enolate.
    Keywords
    Upper-Division Undergraduate, Organic Chemistry, Green Chemistry, Hands-On Learning / Manipulatives, Aldehydes / Ketones
    DOI: 10.1021/ed083p1333
    ADLID: 21539-v4
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  1. Keywords
    Upper-Division Undergraduate Organic Chemistry Green Chemistry Hands-On Learning / Manipulatives Aldehydes / Ketones
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