2. Author's Information
    Joost P. Bruggeman
    Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)

    Christopher J. Bettinger
    Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)

    Christiaan L.E. Nijst
    Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)

    Daniel S. Kohane
    Department of Anaesthesiology, Children`s Hospital Harvard Medical School Boston, MA 02114 (USA)

    Robert Langer
    Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
  3. Abstract
    Synthetic polymers composed of metabolites endogenous to the mammalian organism are designed. The design is based on the monomer xylitol, which possesses a wide range of physical properties that are biologically relevant. Xylitol-based hydrogels and elastomers are biocompatible in vitro and in vivo, compared to the prevalent synthetic polymer poly(L-lactic-co- glycolic acid) (PLGA). It furthermore provides a platform to tune mechanical properties, degradation profiles, and cell attachment.
    Keywords
    Biodegradable materials, elastomers, hydrogels, biomaterials, xylitol, polymers, biomedical applications
    DOI: 10.1002/adma.200702377
    ADLID: 65902-v7
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  1. Keywords
    Biodegradable materials elastomers hydrogels biomaterials xylitol polymers biomedical applications
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