Degradation of incurred tylosin to desmycosin—Implications for residue analysis of honey

Research Article | Analytica Chimica Acta
Degradation of incurred tylosin to desmycosin—Implications for residue analysis of honey
Author's Information

Thomas S. Thompson

Alberta Agriculture, Food & Rural Development (AAFRD), Food Safety Division, Agri-Food Laboratories Branch, 6909, 116th Street, Edmonton, Alberta, Canada T6H 4P2

Stephen F. Pernal

Agriculture & Agri-Food Canada (AAFC), P.O. Box 29, Beaverlodge, Alberta, Canada T0H 0C0

Donald K. Noot

Alberta Agriculture, Food & Rural Development (AAFRD), Food Safety Division, Agri-Food Laboratories Branch, 6909, 116th Street, Edmonton, Alberta, Canada T6H 4P2

Adony P. Melathopoulos

Agriculture & Agri-Food Canada (AAFC), P.O. Box 29, Beaverlodge, Alberta, Canada T0H 0C0

Johan P. van den Heever

Alberta Agriculture, Food & Rural Development (AAFRD), Food Safety Division, Agri-Food Laboratories Branch, 6909, 116th Street, Edmonton, Alberta, Canada T6H 4P2
Abstract

As a result of the application of tylosin to honey bee colonies for the control of American foulbrood disease, antibiotic residues may exist in honey destined for human consumption. It has been recognized that the parent compound, tylosin A, degrades in acidic media such as honey to yield the antimicrobially active degradation product, desmycosin. Data is presented documenting levels of incurred tylosin and desmycosin in honey resulting from simulated therapeutic applications of a commercial formulation of tylosin during the fall. It is demonstrated that honey destined for human consumption should be analyzed for both tylosin A and desmycosin (tylosin B) rather than the parent antibiotic alone. An analytical method that permits the simultaneous determination of tylosin A and desmycosin in honey using liquid chromatography–tandem mass spectrometry is also presented.

Keywords

Tylosin, Desmycosin, Antibiotics, Honey, Residues, Liquid chromatography–tandem mass spectrometry (LC–MS/MS), American foulbrood (AFB), Paenibacillus larvae

DOI: 10.1016/j.aca.2006.09.043

ADLID: 80641-v1

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Keywords
Tylosin Desmycosin Antibiotics Honey Residues Liquid chromatography–tandem mass spectrometry (LC–MS/MS) American foulbrood (AFB) Paenibacillus larvae

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